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Background  Chagas disease is caused by  Trypanosoma cruzi , a parasite endemic to Latin America. Most infections occur in children by vector or congenital transmission.  Trypanosoma cruzi  establishes a complexity of specific molecular parasite-host cell interactions to invade the host. However, most studies have been mainly focused on the interaction between the parasite and different cell types, but not on the infection and invasion on a tissue level. During congenital transmission,  T. cruzi  must cross the placental barrier, composed of epithelial and connective tissues, in order to infect the developing fetus. Here we aimed to study the global changes of transcriptome in the placental tissue after a  T. cruzi  challenge .Results  Strong changes in gene expression profiling were found in the different experimental conditions, involving the reprogramming of gene expression in genes involved in the innate immune response.    Conclusions   Trypanosoma cruzi  induces strong changes in genes involved in a wide range of pathways, especially those involved in immune response against infections.    Electronic supplementary material  The online version of this article (10.1186/s13071-018-2988-0) contains supplementary material, which is available to authorized users.

Host-parasite interaction: changes in human placental gene expression induced by Trypanosoma cruzi