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Background  There is a continuing need for novel approaches to tick infestations treatment and control in cats. Lotilaner, an isoxazoline with rapid onset of action, has proven its efficacy against ticks in laboratory studies. A study was undertaken to confirm lotilaner’s efficacy and safety in client-owned cats, at the minimum dose of 6.0 mg/kg, against the most common ticks infesting cats in Europe.    Methods  Twenty clinics in Germany, Hungary and Portugal participated in the study. Households with no more than three cats were randomized 2:1 to a lotilaner or fipronil group. The first household cat with at least three live, attached ticks was the primary cat. Treatments were dispensed on days 0, 28 and 56 for owner administration. Tick counts were performed on days 0, 7, 14, 21, 28, 42, 56, 70 and 84 (primary cats) and supplementary cats were assessed for safety only, on days 28, 56 and 84. Efficacy was assessed by comparing mean day 0 live attached tick counts with subsequent counts.    Results  Most frequently retrieved ticks were  Ixodes ricinus ,  Rhipicephalus sanguineus  and  Dermacentor reticulatus , with  Ixodes hexagonus  also present. In the lotilaner group ( n  = 112) efficacy (based on geometric mean tick counts) was between 98.3–100%. For fipronil ( n  = 57), efficacy was between 89.6–99.6%, with live attached ticks present on some cats at all time points. Mean tick counts in lotilaner-treated cats were significantly lower than in fipronil-treated cats on days 21, 28, 42 and 56 ( P  < 0.05). The mean percent efficacy over all post-enrolment visits was 99.6% and 96.4% (lotilaner and fipronil group, respectively), ( P  < 0.0001). Lotilaner was superior to fipronil for efficacy averaged over all time points ( P  < 0.0001) and on individual assessment days (day 14 to 70,  P  < 0.0394); it was non-inferior to fipronil on the other days. Owners successfully administered all treatments, and both products were well tolerated.    Conclusions  Credelio TM  was effective and safe for the treatment of tick infestations in client-owned cats. Efficacy lasted one month and lotilaner was superior to fipronil on most assessment days. Cure rates ranged between 94.5–100% for lotilaner and 68.4–98.2% for fipronil.    Electronic supplementary material  The online version of this article (10.1186/s13071-018-2967-5) contains supplementary material, which is available to authorized users.

A randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio™) in controlling ticks in client-owned cats in Europe