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Background  Northern fowl mite,  Ornithonyssus sylviarum  (Canestrini & Fanzago, 1877), infestations can stress birds, impairing welfare and causing substantial economic losses. A study was undertaken to determine the efficacy of an ectoparasiticide solution (fluralaner) for oral administration in the treatment of mite-infested hens.    Methods  Clinically healthy, naturally mite-infested laying hens ( n  = 132), approximately 32 weeks of age, were ranked by Day -9 mite vent counts and randomized among 12 study pens, each to hold one of four treatment groups. Three groups received fluralaner-medicated water by oral gavage at dose rates of 0.25, 0.5 or 1.0 mg/kg on Days 0 and 7; one group was an untreated control (three pens for each group). Five naturally infested untreated birds were included in each pen to act as mite-infested source birds. Thus each pen, treated and control, had six non-source birds for assessment of efficacy, plus five source birds to provide ongoing challenge. Primary efficacy assessments were based on mean  O. sylviarum  vent counts from non-source birds in the control and treated group pens on Days 1, 2, 6, 8, 12, 15, 19, 22 and 26.    Results  Source-birds maintained infestations throughout the study, validating the challenge to study birds. On Days 1 through 22, mean control group mite counts were significantly greater than those of the treated groups ( P  ≤ 0.013). Relative to the control group, mean  O. sylviarum  counts were reduced by at least 90% from Day 6 through Days 19, 22 and 22 in the fluralaner 0.25, 0.5 and 1.0 mg/kg groups, respectively. On Day 19, mean mite counts were lower in the 0.5 and 1.0 mg/kg groups compared with the 0.25 mg/kg group ( P  ≤ 0.018), and in the 1.0 mg/kg compared with the 0.5 mg/kg group ( P  = 0.014). There were no adverse events in treated birds.    Conclusions  A fluralaner solution administered twice by gavage to laying hens with a one-week between-treatment interval was safe and effective in quickly controlling  O. sylviarum  infestations despite continuous challenge from infested birds. By eliminating mites, this fluralaner solution has the potential to improve bird health and productivity, and to eliminate the burden of topical pesticide application.

parasites and vectors

Efficacy and safety assessment of a water-soluble formulation of fluralaner for treatment of natural Ornithonyssus sylviarum infestations in laying hens