English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Low-density asymptomatic infections of  Plasmodium  spp. are common in low endemicity areas worldwide, but outside Africa, their contribution to malaria transmission is poorly understood. Community-based studies with highly sensitive molecular diagnostics are needed to quantify the asymptomatic reservoir of  Plasmodium falciparum  and  P. vivax  infections in Thai communities.    Methods  A cross-sectional survey of 4309 participants was conducted in three endemic areas in Kanchanaburi and Ratchaburi provinces of Thailand in 2012. The presence of  P. falciparum  and  P. vivax  parasites was determined using 18S rRNA qPCR. Gametocytes were also detected by  pfs25 / pvs25  qRT-PCRs.    Results  A total of 133 individuals were found infected with  P. vivax  (3.09%), 37 with  P. falciparum  (0.86%), and 11 with mixed  P. vivax/ P. falciparum  (0.26%). The clear majority of both  P. vivax  (91.7%) and  P. falciparum  (89.8%) infections were not accompanied by any febrile symptoms. Infections with either species were most common in adolescent and adult males. Recent travel to Myanmar was highly associated with  P. falciparum  (OR = 9.0,  P  = 0.001) but not  P. vivax  infections ( P  = 0.13). A large number of  P. vivax  (71.5%) and  P. falciparum  (72.0%) infections were gametocyte positive by  pvs25/pfs25  qRT-PCR. Detection of gametocyte-specific  pvs25  and  pfs25  transcripts was strongly dependent on parasite density.  pvs25  transcript numbers, a measure of gametocyte density, were also highly correlated with parasite density ( r   2  = 0.82,  P  < 0.001).    Conclusions  Asymptomatic infections with  Plasmodium  spp. were common in western Thai communities in 2012. The high prevalence of gametocytes indicates that these infections may contribute substantially to the maintenance of local malaria transmission.    Electronic supplementary material  The online version of this article (10.1186/s13071-017-2407-y) contains supplementary material, which is available to authorized users.

Very high carriage of gametocytes in asymptomatic low-density Plasmodium falciparum and P. vivax infections in western Thailand