English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Tick-borne diseases currently represent an important issue for global health. A number of emerging tick-transmitted microbes continue to be discovered, and some of these are already identified as the cause of human infections. Over the past two decades,  Anaplasma phagocytophilum  is considered to be mainly responsible for human anaplasmosis. However, a novel zoonotic pathogen provisionally named “ Anaplasma capra ” has recently been identified in China. In this study, we did an active surveillance of  A. capra  in goats and sheep in different geographical regions of China.    Methods  The presence of  A. capra  was determined by nested PCR in 547 blood samples collected from goats and sheep from 24 counties distributed in 12 provinces in China. The molecular characterization of  A. capra  isolates in sheep and goats was achieved based on four conventional genetic markers (16S rRNA,  gltA ,  groEL  and  msp4  genes).    Results    Anaplasma capra  was identified in 75 of 547 animals, with an overall prevalence of 13.7%. The infection rates in the survey sites ranged from 0 to 78.6%, and were significantly different ( P  < 0.01). Phylogenetic analysis revealed that the isolates obtained from goats, sheep,  Ixodes persulcatus  ticks and humans create a separate clade within the genus  Anaplasma  and distinct from other recognized  Anaplasma  species. These findings indicated that these  A. capra  isolates possess the same molecular characteristics, suggesting that this organism could be a substantial health threat to both animals and humans.    Conclusions    Anaplasma capra  is an emerging tick-transmitted zoonotic pathogen. This novel  Anaplasna  species is widespread across China with an overall prevalence of 13.7% in goats and sheep with isolates indistinguishable from those found in humans. These findings warrant increased public health awareness for human anaplasmosis.

A novel zoonotic Anaplasma species is prevalent in small ruminants: potential public health implications