English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background   Rhipicephalus appendiculatus  is the primary vector of  Theileria parva , the etiological agent of East Coast fever (ECF), a devastating disease of cattle in sub-Saharan Africa. We hypothesized that a vaccine targeting tick proteins that are involved in attachment and feeding might affect feeding success and possibly reduce tick-borne transmission of  T. parva . Here we report the evaluation of a multivalent vaccine cocktail of tick antigens for their ability to reduce  R. appendiculatus  feeding success and possibly reduce tick-transmission of  T. parva  in a natural host-tick-parasite challenge model.    Methods  Cattle were inoculated with a multivalent antigen cocktail containing recombinant tick protective antigen subolesin as well as two additional  R. appendiculatus  saliva antigens: the cement protein TRP64, and three different histamine binding proteins. The cocktail also contained the  T. parva  sporozoite antigen p67C. The effect of vaccination on the feeding success of nymphal and adult  R. appendiculatus  ticks was evaluated together with the effect on transmission of  T. parva  using a tick challenge model.    Results  To our knowledge, this is the first evaluation of the anti-tick effects of these antigens in the natural host-tick-parasite combination. In spite of evidence of strong immune responses to all of the antigens in the cocktail, vaccination with this combination of tick and parasite antigens did not appear to effect tick feeding success or reduce transmission of  T. parva .    Conclusion  The results of this study highlight the importance of early evaluation of anti-tick vaccine candidates in biologically relevant challenge systems using the natural tick-host-parasite combination.    Electronic supplementary material  The online version of this article (doi:10.1186/s13071-016-1774-0) contains supplementary material, which is available to authorized users.

parasites and vectors

Induction of humoral immune response to multiple recombinant Rhipicephalus appendiculatus antigens and their effect on tick feeding success and pathogen transmission