English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Over the last few decades, pyrethroid-resistant in  Triatoma infestans  populations have been reported, mainly on the border between Argentina and Bolivia. Understanding the genetic basis of inheritance mode and heritability of resistance to insecticides under laboratory conditions is crucial for vector management and monitoring of insecticide resistance. Currently, few studies have been performed to characterize the inheritance mode of resistance to pyrethroids in  T. infestans ; for this reason, the present study aims to characterize the inheritance and heritability of deltamethrin resistance in  T. infestans  populations from Bolivia with different toxicological profiles.    Methods  Experimental crosses were performed between a susceptible (S) colony and resistant (R) and reduced susceptibility (RS) colonies in both directions (♀ x ♂ and ♂ x ♀), and inheritance mode was determined based on degree of dominance (DO) and effective dominance (D  ML  ). In addition, realized heritability (h 2 ) was estimated based on a resistant colony, and select pressure was performed for two generations based on the diagnostic dose (10 ng. i. a. /nymph). The F1 progeny of the experimental crosses and the selection were tested by a standard insecticide resistance bioassay.    Results  The result for DO and D  ML   (< 1) indicates that resistance is an incompletely dominant character, and inheritance is autosomal, not sex-linked. The LD 50  for F1 of ♀S x ♂R and ♂S x ♀R was 0.74 and 3.97, respectively, which is indicative of dilution effect. In the resistant colony, after selection pressure, the value of h 2  was 0.37; thus, the LD 50  value increased 2.25-fold (F2) and 26.83-fold (F3) compared with the parental colony.    Conclusion  The inheritance mode of resistance of  T. infestans  to deltamethrin, is autosomal and an incompletely dominant character; this is a previously known process, confirmed in the present study on  T. infestans  populations from Bolivia. The lethal doses (LD 50 ) increase from one generation to another rapidly after selection pressure with deltamethrin. This suggests that resistance is an additive and cumulative factor, mainly in highly structured populations with limited dispersal capacity, such as  T. infestans . This phenomenon was demonstrated for the first time for  T. infestans  in the present study. These results are very important for vector control strategies in problematic areas where high resistance ratios of  T. infestans  have been reported.

Inheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia