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Background  The preventive effect of fluralaner chewable tablets (Bravecto™) against transmission of  Babesia canis  by  Dermacentor reticulatus  ticks was evaluated.    Methods  Sixteen dogs, tested negative for  B. canis  by PCR and IFAT, were allocated to two study groups. On day 0, dogs in one group ( n  = 8) were treated once orally with a fluralaner chewable tablet according to label recommendations and dogs in the control group ( n  = 8) remained untreated. On days 2, 28, 56, 70 and 84, dogs were infested with 50 (±4)  B. canis  infected  D. reticulatus  ticks with tick in situ thumb counts 48 ± 4 h post-infestation. Prior to each infestation, the  D. reticulatus  ticks were confirmed to harbour  B. canis  by PCR analysis. On day 90, ticks were counted and removed from all dogs. Efficacy against ticks was calculated for each assessment time point. After treatment, all dogs were physically examined in conjunction with blood collection for PCR every 7 days, blood samples for IFAT were collected every 14 days and the dog’s rectal body temperature was measured thrice weekly. From dogs displaying symptoms of babesiosis or were PCR positive, a blood smear was taken, and, if positive, dogs were rescue treated and replaced with a replacement dog. The preventive effect was evaluated by comparing infected dogs in the treated group with infected dogs in the untreated control group.    Results  All control dogs became infected with  B. canis , as confirmed by PCR and IFAT. None of the 8 treated dogs became infected with  B. canis , as IFAT and PCR were negative throughout the study until day 112. Fluralaner chewable tablet was 100 % effective against ticks on days 4, 30, 58, and 90 and an efficacy of 99.6 % and 99.2 % was achieved on day 72 and day 86 after treatment, respectively. Over the 12-week study duration, a 100 % preventive effect against  B. canis  transmission was demonstrated.    Conclusions  A single oral administration of fluralaner chewable tablets effectively prevented the transmission of  B. canis  by infected  D. reticulatus  ticks over a 12-week period.

Prevention of transmission of Babesia canis by Dermacentor reticulatus ticks to dogs treated orally with fluralaner chewable tablets (Bravecto™)