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A series of novel 4-thiazolidinone inhibitors  SKYa – SKYg , containing coumarin as a core structure were synthesized via facile and efficient method. The structures of the synthesized compounds were established by extensive spectroscopic studies (FT IR, 1D NMR, 2D NMR, LC–MS) and elemental analysis. All the synthesized hybrids were further evaluated for their potential as anti-tubercular agents against  Mycobacterium tuberculosis  H37Rv ATCC 25618, and anti-bacterial agents against  Escherichia coli, Enterobacter aerogenes, Salmonella typhi, Streptococcus pneumoniae  and  Staphylococcus aureus . Interestingly, the hybrids displayed potent bioactivity. However, compounds  SKYc ,  SKYd , and  SKYe  appeared to be more effective against the tested bacterial strains, among which compound  SKYb  showed the highest inhibition against all the bacterial strains ranging from 41 to 165 μg/mL, as compared to the standards, streptomycin, kanamycin and vancomycin. Moreover, derivative  SKYa  was found to be the strongest against  M. tuberculosis  (83 μg/mL). Additionally, the anti-dengue potential of the coumarin hybrids as two-component NS2B/NS3 DENV flavivirus serine protease inhibitors was calculated using computational molecular docking approach, with reference to the standards 4-hydroxypanduratin, panduratin and ethyl 3-(4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy)propanoate with DS of − 3.379, − 3.189 and − 3.381, respectively. The docking results revealed that the synthesized hybrids exhibited potent anti-dengue activity among which compounds  SKYf ,  SKYd ,  SKYc  and  SKYe  were found to be the best ones with docking scores of − 4.014, − 3.964, − 3.905 and − 3.889. In summary, we discovered 4-thiazolidinone coumarin derivatives as a new scaffold that may eventually yield useful compounds in the treatment of bacterial and viral infections.Electronic supplementary material  The online version of this article (10.1186/s13065-018-0435-0) contains supplementary material, which is available to authorized users.

chemistry central journal

4-Thiazolidinone coumarin derivatives as two-component NS2B/NS3 DENV flavivirus serine protease inhibitors: synthesis, molecular docking, biological evaluation and structure–activity relationship studies