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Background  Pyrimidine is an aromatic heterocyclic moiety containing nitrogen atom at 1st and 3rd positions and play an important role to forms the central core for different necessity of biological active compounds, from this facts, we have designed and synthesized a new class of pyrimidin-2-ol/thiol/amine derivatives and screened for its in vitro antimicrobial activity.    Results and discussion  The synthesized pyrimidine derivatives were confirmed by IR,  1 H/ 13 C-NMR, Mass spectral studies and evaluated for their in vitro antimicrobial potential against Gram positive ( S. aureus  and  B. subtilis ), Gram negative ( E. coli, P. aeruginosa  and  S. enterica ) bacterial strains and fungal strain ( C. albicans  and  A. niger ) by tube dilution method and recorded minimum inhibitory concentration in µM/ml. The MBC and MFC values represent the lowest concentration of compound that produces in the range of 96–98% end point reduction of the used test bacterial and fungal species.    Conclusion  In general all synthesized derivatives exhibited good antimicrobial activity. Among them, compounds  2, 5, 10, 11  and  12  have significant antimicrobial activity against used bacterial and fungal strains and also found to be more active than the standard drugs.  Graphical abstract   Pyrimidine is an aromatic heterocyclic moiety containing nitrogen atom at 1st and 3rd positions and play an important role to forms the central core for different necessity of biological active compounds, from this facts, we have designed and synthesized a new class of pyrimidin-2-ol/thiol/amine derivatives and screened for its in vitro antimicrobial activity. The synthesized pyrimidine derivatives were confirmed by IR, 1H/13C-NMR, Mass spectral studies and evaluated for their in vitro antimicrobial potential against Gram positive ( S. aureus  and  B. subtilis ), Gram negative ( E. coli ,  P. aeruginosa  and  S. enterica ) bacterial strains and fungal strain ( C. albicans  and  A. niger ) by tube dilution method and recorded minimum inhibitory concentration in µM/ml. The MBC and MFC values represent the lowest concentration of compound that produces in the range of 96–98% end point reduction of the used test bacterial and fungal species.

Design, synthesis and antimicrobial evaluation of pyrimidin-2-ol/thiol/amine analogues