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Background  We aimed to enhance the solubility, dissolution properties, and skin-whitening ability of ferulic acid (FA) by preparing a ferulic acid–phospholipid complex (FA–PC). The properties and melanogenesis inhibition activities of FA–PC were then elucidated.    Methods  We characterized the complex via differential scanning calorimetry, Fourier transform infrared spectroscopy, scanning electron microscopy, solubility, and oil–water partition coefficient. A Strat-M ®  membrane, a synthetic membrane possessing diffusion characteristics that are well-correlated with human skin, was used for the diffusion studies of FA–PC.    Results  We found that the lipophilicity of FA improved when complexed with phospholipids, allowing FA–PC to release FA in a controlled pattern. In the same time, complexing with phospholipids also obviously enhanced inhibition of B16F10 cellular melanogenesis.    Conclusions  FA–PC is a promising material for medicinal and cosmetic usages.

Preparation of a ferulic acid–phospholipid complex to improve solubility, dissolution, and B16F10 cellular melanogenesis inhibition activity