English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background    Ptycholobium  is a genus related to  Tephrosia  which comprises only three species. Compared to  Tephrosia , which has been phytochemically and pharmacologically studied,  Ptycholobium  species have only few or no reports on their chemical constituents. Moreover, no studies on the cytotoxic activities of its secondary metabolites have been previously documented.    Results  From the non polar fractions of the roots bark of  Ptycholobium contortum  (syn  Tephrosia contorta ), two new pterocarpans: seputhecarpan C  1  and seputhecarpan D  2  and a new pyrone derivative, ptycholopyrone A  3  were isolated. Alongside, five known compounds identified as 3-α,α-dimethylallyl-4-methoxy-6-styryl-α-pyrone or mundulea lactone  4 , glyasperin F  5 , seputhecarpan A  6 , seputheisoflavone  7  and 5- O -methyl-myo-inositol or sequoyitol  8  were also obtained. Their structures were established by the mean means of spectroscopic data in conjunction to those reported in literature. The NMR assignment of the major compound mundulea lactone  4  is revised in this paper. In addition, the cytotoxicity of the isolated metabolites was evaluated on two lung cancer cell lines A549 and SPC212.  8  was not active while compounds  1, 2, 4–7  displayed antiproliferative effects against the two carcinoma cell lines with IC 50  values below 75 µM. IC 50  values below 10 µM were obtained for  4, 6  and  7  on SPC212 cells.    Conclusion  Based on the obtained results,  Ptycholobium contortum  turns to be a rich source of phenolic metabolites among them some bearing prenyl moieties. This study reports for the first time the isolation of pyrone derivatives  3  and  4  from  Ptycholobium  genus. The cytotoxicity observed for the isolate is also reported for the first time and shows that  4, 6  and  7  could be chemically explored in order to develop a hit candidate against lung cancer.   Graphical abstract   Two new pterocarpans and a new pyrone derivative with cytotoxic activities from ptycholobium contortum (N.E.Br.) Brummitt (Leguminosae): revised NMR assignment of mundulea lactone.Electronic supplementary material  The online version of this article (doi:10.1186/s13065-016-0204-x) contains supplementary material, which is available to authorized users.

chemistry central journal

Two new pterocarpans and a new pyrone derivative with cytotoxic activities from Ptycholobium contortum (N.E.Br.) Brummitt (Leguminosae): revised NMR assignment of mundulea lactone