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A concise route for the synthesis of Fingolimod is reported. Starting from n-octylbenzene and 3-nitropropionic acid, a sequence of reactions consisting of Friedel-Crafts acylation, reduction, and double Henry reaction, followed by hydrogenation were applied to prepare Fingolimod with a yield of 31%, and an overall atom economy of 82.7%.    Graphical Abstract   Starting from 3-nitropropanyl chloride, Fingolimod was obtained in 4 steps with an overall yield of 31%.

A concise synthesis of Fingolimod: an orally available drug for treating multiple sclerosis