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Genus  Syringa , belonging to the Oleaceae family, consists of more than 40 plant species worldwide, of which 22 species, including 18 endemic species, are found in China. Most  Syringa  plants are used in making ornaments and traditional medicines, whereas some are employed for construction or economic use. Previous studies have shown that extracts of  Syringa  plants mainly contain iridoids, lignans, and phenylethanoids that have antitumor, antihypertensive, anti-oxidant, and anti-inflammatory activities. This study reviews phytochemical and pharmacological progress on  Syringa  in the recent 20 years and discusses the future research prospects to provide a reference in further promotion and application of the genus.    Graphical Abstract   Phytochemical and pharmacological progress on the genus  Syringa