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Background  It is seen that the regioselective functionalizations of halogenated heterocycles play an important role in the synthesis of several types of organic compounds. In this domain, the Suzuki-Miyaura reaction has emerged as a convenient way to build carbon-carbon bonds in synthesizing organic compounds. Some of the most important applications of these reactions can be seen in the synthesis of natural products, and in designing targeted pharmaceutical compounds. Herein, we present the regioselective synthesis of the novel series of 2-(bromomethyl)-5-aryl-thiophenes  3a-i,  via  Suzuki cross-coupling reactions of various aryl boronic acids with 2-bromo-5-(bromomethyl)thiophene  (2) .    Results  The synthesized compounds were screened for their haemolytic and antithrombolytic activities. The novel compounds  3f, 3i  showed highest 69.7, 33.6% haemolysis of blood cells, respectively. The antithrombolytic activity of the compounds was found to be within low to moderate against human blood clot. The compound  3i  showed potent clot lysis (31.5%).    Conclusions  Considering these results, it is concluded that the synthesized compounds can be used as a promising source of therapeutic agents.

chemistry central journal

Regioselective synthesis of 2-(bromomethyl)-5-aryl-thiophene derivatives viapalladium (0) catalyzed suzuki cross-coupling reactions: as antithrombotic and haemolytically active molecules