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Background  Postprandial distress syndrome manifests as a feeling of fullness and early satiation that can significantly reduce the quality of life of the patients. In Chinese medicine (CM), the syndrome is traditionally regarded as the  Wei-Pi  syndrome, and Banxia Xiexin decoction (BXD) has been used in the empirical treatment of the same for a long time. The current study aims to evaluate the efficacy of modified BXD in the management of  Wei-Pi  syndrome.    Methods/design  A randomized, waitlist-controlled trial will be conducted. A total of 84 patients with  Wei-Pi  syndrome will be randomized into the BXD or waitlist control group in a ratio of 1:1. The patients in the BXD group will receive the semi-individualized BXD on the basis of the syndrome differentiation in CM, for a duration of 3 weeks and will be under follow-up for further 3 weeks after the completion of therapy. Conversely, the patients in the waitlist control group will undergo the same intervention and follow-up after a 3-week waiting period. In the current study, the primary outcome will be the variation in the scores pertaining to the global scale of the Quality of Life Questionnaire for Functional Digestive Disorders after 3 weeks. The secondary outcomes include the variations in the scores pertaining to the Hospital Anxiety and Depression Scale and the EuroQoL 5-dimension 5-level Questionnaire and the results of the liver and kidney function tests.    Discussion  This trial will assess the efficacy of modified BXD in improving the clinical symptoms and quality of life of the patients suffering from  Wei-Pi  syndrome.    Trial registration   ClinicalTrials.gov  NCT04398888 . Registered on May 21, 2020    Supplementary Information  The online version contains supplementary material available at 10.1186/s13063-021-05078-y.

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Efficacy of modified Banxia Xiexin decoction in the management of Wei-Pi syndrome (postprandial distress syndrome): study protocol for a randomized, waitlist-controlled trial