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Background  School-based comprehensive sexual health education can improve adolescent health outcomes, and web-based programs are a promising approach to overcoming challenges associated with teacher-led formats by ensuring that students receive content that is consistent, unbiased, and medically accurate. However, many adolescents do not receive high-quality sexual health education and turn to the media for information about sex and relationships. Consumption of sexual media messages is related to early and risky sexual behaviors. Media literacy education (MLE) is a proven approach to adolescent sexual health promotion, yet there are no rigorously evaluated web-based MLE programs to promote sexual and relationship health among high school students.    Methods  This study will test the efficacy, in a randomized controlled trial, of  Media Aware , a web-based comprehensive sexual health promotion program for high school students that uses an MLE approach. Participants will be students in 9th and 10th grade health classes in participating schools. Randomization will take place at the school level, and data collection will take place at three time points (i.e., pretest, posttest, and 3 months follow-up). Students in the intervention classrooms will receive  Media Aware  between pretest and posttest, and students in the delayed-intervention classrooms will receive  Media Aware  after study completion (i.e., after 3 months follow-up data collection). Students in the delayed-intervention classes will receive their standard health education programming, and teachers in the delayed-intervention classes will be asked to refrain from teaching sexual health or MLE during the study timeframe. The primary outcome variables are intentions, willingness, and behaviors related to sexual health and sexual activity.    Discussion  There are currently no evidence-based comprehensive sexual health programs for high school students that are web-based and use an MLE approach.  Media Aware  has the potential to be an engaging, less expensive, and effective sexual and relationship health program for high school students.  Media Aware  is unique in two important ways: (1) the web-based format reduces many of the challenges to fidelity of implementation associated with teacher-led sexual health education; and (2) the MLE approach addresses a commonly ignored influence on adolescent sexual and relationship health, namely, media.    Trial registration  ClinicalTrials.gov,  NCT04035694 . Registered on 29 July 2019.   Contact for Scientific Queries:  Tracy Scull, PhD (Principal Investigator); innovation Research & Training at 5316 Highgate Drive, Suite 121, Durham, North Carolina, USA 27713; tscull@irtinc.us.

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Study protocol for a randomized controlled trial to evaluate a web-based comprehensive sexual health and media literacy education program for high school students