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Correspondence: taotaovip2005@ 163.com; shengtaozhou@scu.edu.cn Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, People’s Republic of China Today, we have entered a data-explosive realm, which requires us to have a rational and clear viewpoint to visualize the underlying contour of a spectrum of events, especially life sciences. Cancer biology, as an important branch of life sciences, also experiences an explosion of data and related molecular characterization. Our evolving understanding of cancer hallmarks derives from rapid progress in the development of multiomics technologies. According to PubMed, omics-based investigations, either single omics or multiomics, of a variety of cancer types have been expanding each year. Correspondingly, our conception of this deadly disease no longer stays at a mono-gene level, but becomes more multidimensional and network-based. In this context, Genome Biology has launched this special issue entitled “Cancer Evolution and Metastasis” incorporating articles that give us additional explanation for the molecular mechanisms driving cancer evolution, heterogeneity, and metastasis. These resources will give us a bird’s-eye view of how intra-tumor and inter-tumor heterogeneity formed and how we can rationally design optimized treatment strategies based upon these discoveries.

Multiomics kaleidoscope to visualize cancer hallmarks