English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Tsetse flies ( Glossina  sp.) are the vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. Tsetse flies are distinguished from other Diptera by unique adaptations, including lactation and the birthing of live young (obligate viviparity), a vertebrate blood-specific diet by both sexes, and obligate bacterial symbiosis. This work describes the comparative analysis of six  Glossina  genomes representing three sub-genera:  Morsitans  ( G. morsitans morsitans ,  G. pallidipes ,  G. austeni ),  Palpalis  ( G. palpalis ,  G. fuscipes ), and  Fusca  ( G. brevipalpis ) which represent different habitats, host preferences, and vectorial capacity.    Results  Genomic analyses validate established evolutionary relationships and sub-genera. Syntenic analysis of  Glossina  relative to  Drosophila melanogaster  shows reduced structural conservation across the sex-linked X chromosome. Sex-linked scaffolds show increased rates of female-specific gene expression and lower evolutionary rates relative to autosome associated genes. Tsetse-specific genes are enriched in protease, odorant-binding, and helicase activities. Lactation-associated genes are conserved across all  Glossina  species while male seminal proteins are rapidly evolving. Olfactory and gustatory genes are reduced across the genus relative to other insects. Vision-associated Rhodopsin genes show conservation of motion detection/tracking functions and variance in the Rhodopsin detecting colors in the blue wavelength ranges.    Conclusions  Expanded genomic discoveries reveal the genetics underlying  Glossina  biology and provide a rich body of knowledge for basic science and disease control. They also provide insight into the evolutionary biology underlying novel adaptations and are relevant to applied aspects of vector control such as trap design and discovery of novel pest and disease control strategies.    Electronic supplementary material  The online version of this article (10.1186/s13059-019-1768-2) contains supplementary material, which is available to authorized users.

Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes