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An important application of modern genomics is diagnosing genetic disorders. We use the largest publicly available exome sequence database to show that this key clinical service can currently be performed much more effectively in individuals of European genetic ancestry.   Electronic supplementary material  The online version of this article (doi:10.1186/s13059-016-1016-y) contains supplementary material, which is available to authorized users.

Unequal representation of genetic variation across ancestry groups creates healthcare inequality in the application of precision medicine