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Javaudin et al. [1] recommended that for cases of out-ofhospital cardiac arrest (OHCA) for which a cause is not obvious, pulmonary embolism (PE) should be suspected if the initial rhythm is nonshockable and there is a history of thromboembolism (TE). In accordance with the guidelines of the American Heart Association, these patients could be treated with systemic thrombolysis (ST) during resuscitation (low level of evidence) [1]. We would like to add some comments. First, recent studies have shown that ultrasound-facilitated catheter fibrinolysis relieves right ventricular pressure overload with a lower risk of major bleeding and intracranial hemorrhage than historical rates with ST [2]. However, further research is required to determine the optimal application of this technique in the setting of acute PE [2]. Second, the insertion of an emergency veno-arterial extracorporeal membrane oxygenation (VA-ECMO) catheter should be considered before starting ST. VA-ECMO can be a lifesaving therapeutic consideration, either as an adjunct to definitive management strategies (surgical/catheter embolectomy, thrombolysis) or on its own [3]. According to a recent systematic review, VAECMO for selected patients with massive PE is associated with good outcome [3]. Third, after failure of thrombolysis, surgical embolectomy or catheter embolectomy should be considered in selected centers [3]. Fourth, published cases of thrombolysis for massive PE during pregnancy and the postpartum

Thrombolytic therapy during resuscitation for pulmonary embolism-related out-of-hospital cardiac arrest: perhaps not the ideal solution for everyone