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Pathogens are known to survive on surfaces in health care environments despite routine cleaning and nearly always cause nosocomial infections [1–3]. The number of health care-associated infections is progressively increasing and the extent of multidrug-resistant organisms (MDROs) in medical institutions is of worldwide concern and continues to challenge infection control [4, 5]. The aim of our study was to find the simplest and most effective way to reduce the spread of MDROs by using “infection grade ward isolation” (IGWI). We conducted a 1-year prospective study to evaluate the impact of the IGWI method on MDRO environmental contamination and colonization in the intensive care unit (ICU). The study comprised a 3-month baseline period and a 9-month intervention period. The baseline period ranged from March 1, 2018, to May 31, 2018. There was no difference between ICU-1 (10 single rooms and 5 double rooms with 20 beds) and ICU-2 (newly built, 2 multi-bed rooms with 12 beds) in terms of patient admission, medication, and ward disinfection. The intervention period lasted from June 1, 2018, to February 28, 2019. During this period, IGWI was implemented; patients with MDRO infections or who used more than a third-generation cephalosporins or other strong antibiotics were not allowed into ICU-2, and patients in ICU-2 needing advanced antibiotics or with newly found MDROs were quickly transferred to ICU-1. Both wards had noninterchangeable equipment, work clothes, and noninteracting staff. Samples from five different surfaces—an air conditioning vent, an oxygenation probe, an intravenous pump, a bed rail button, and a sheet (from around the perineal area of the patient)—from 32 beds (20 beds in ICU-1 and 12 beds in ICU-2) were collected on sterile rayon swabs each month, which were then cultured for the presence of MDROs. We collected 1920 swabs over 1 year—1200 from ICU-1 and 720 from ICU-2—480 were collected during the baseline period and 1440 during the intervention period. Of these 1920 swabs, 73 were MDRO positive (Table 1). During the baseline period, the MDRO detection rate was 6.7 ~ 10.0% (Table 2), and there was no difference in the incidence of MDROs (6.7 vs. 10.0%, P = 0.109, Table 2) between ICU-2 and ICU-1. During the intervention period using the IGWI method, the MDRO overall detection rate in for both ICU wards was reduced to 0 ~ 3.4% (Table 2). The positive rate of MDROs in the sample cultures was greater in ICU-1 than in ICU-2 (3.4 vs. 0%, P = 0.007). Both wards had a greater proportion of positive results for MDROs during the baseline stage than after the intervention (ICU-1 10 vs. 3.4%, respectively, P < 0.001; ICU-2 6.7 vs. 0%, respectively, P < 0.001; Table 2). We found a very effective technique—the IGWI method—that in essence helps prevent non-MDRO-

Allocation of the ICU wards according to the patient’s infection condition: a measure to improve antibiotic resistance