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Dear Editor, Coronavirus disease 2019 (COVID-19) is associated with severe systemic inflammation and important elevation of fibrinogen and D-dimers that has been associated with a poor prognosis [1, 2]. This proinflammatory state might favor severe thromboembolic events and pulmonary embolism (PE). We retrospectively reviewed characteristics of patients with confirmed SARS-CoV-2 infection and acute PE who were admitted to our tertiary ICU, which serves as an ECMO referral center for the Greater Paris. In accordance with the ethical standards of French legislation, only non-opposition of patient’s surrogate for utilization of the deidentified data was obtained. The ICU database was registered with the national data protection authority (CNIL 1950673). No analysis for statistical significance was performed given the descriptive nature of the study. From February 25, 2020, to April 6, 2020, 51 patients with confirmed SARS-CoV-2 infection were treated in our ICU, of whom 8 (16%) had confirmed severe PE. Patients’ main characteristics are described in Table 1. Four patients had PE while on VV-ECMO for severe ARDS. VAECMO was initiated in 3 other patients with refractory shock due to right ventricular failure, and one patient died of refractory cardiac arrest before ECMO could be installed. PE was suspected in 6 patients because of acute cor pulmonale at echocardiographic evaluation (online supplementary data). PE diagnosis was confirmed by CT angiography (online supplementary data) in 7 patients and by autopsy in one patient. All except one had received anticoagulation before PE diagnosis. Five patients had a very high level of fibrinogen, and all had important increase in D-dimers. As of April 6, 2020, 3 patients had died of multiple organ failure and 5 are still on MV and ECMO in the ICU. We describe a series of 8 critically ill patients with massive PE following COVID-19 infection. Four of these patients developed PE while on VV-ECMO for severe ARDS, a condition that was not reported in the 156 patients included in the EOLIA trial [3] who received ECMO and in the 350 VV-ECMO patients of the LIFEGARDS international multicenter prospective cohort [4]. Interestingly, 7 of the 8 patients had received preventive anticoagulation that did not prevent PE. In 6 of the 8 patients, Doppler echocardiography showing acute right ventricle dilation prompted CT angiography that confirmed PE. Massive PE in COVID-19 patients may be the consequence of sepsis-induced disseminated intravascular coagulation or to a specific procoagulant state caused by inflammation or virus-induced endothelial dysfunction [5]. Important elevation of D-dimers was indeed reported in these patients and was associated with subsequent ARDS and in-hospital mortality [5]. However, massive PE was not reported in previous series [1, 2], although it may have been the unproven cause of death in some patients. Our observation has potential major clinical implications. First, higher level of anticoagulation might be considered in patients with the most severe forms of the disease, those with high D-dimers and, contrarily to our previous recommendation, in patients supported by VV-ECMO [3]. Second, routine Doppler echocardiography should be performed daily to detect early signs of acute cor pulmonale in critically ill

Severe pulmonary embolism in COVID-19 patients: a call for increased awareness