English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

To the Editor: We read with great interest the article published in a recent issue of Critical Care by Brouwer et al. [1]. Authors showed the beneficial effect of addition of CytoSorb filter to continuous renal replacement therapy (CRRT) for hemoadsorption of cytokines in management of septic shock. We would like to raise few points which may be important for authors and readers of the article. This was an investigator-initiated retrospective study of non-consecutive patients, treated by Cytosorb plus CRRT versus CRRT alone. This study was non-randomized, and analysis was not “intention to treat”. We believe both group populations were significantly different (disproportionately higher number of patients in control group with diabetes, hypertension, heart failure, and renal disease and nonsurgical patients) and difference in mortality may just be the result from this difference rather than intervention for the following reasons. Authors describe inclusion of all factors in regression model for determination for its association with treatment allocation; they should acknowledge that investigator initiation itself is a significant factor for bias which cannot be adjusted. Investigator-led management group will likely to have better attention and management. Relatively imperfect attention of physician taking care of patients in control group is reflected by the inappropriate assignment of renal failure as sepsis in 60 out of 109 patients. Authors used propensity score, though treatment effect made using propensity-score matching are valid only if a matched sample of treated and untreated subjects has similar distributions of measured baseline covariates [2]. Figure 2 suggests the difference in mortality only appears after application of “stabilized inverse probability of

Hemoadsorption of cytokines by CytoSorb filter: a simulation study without human factor—pilot is the difference