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Background  Information on regional ventilation distribution in mechanically ventilated patients is important to develop lung protective ventilation strategies. In the present prospective animal study, we introduce an electrical impedance tomography (EIT)-based method to classify lungs into normally ventilated, overinflated, tidally recruited/derecruited and recruited regions.    Methods  Acute respiratory distress syndrome (ARDS) was introduced with repeated bronchoalveolar lavage in ten healthy male pigs until the ratio of arterial partial pressure of oxygen and fraction of inspired oxygen (PaO 2 /FiO 2 ) decreased to less than 100 mmHg and remained stable for 30 minutes. Stepwise positive end-expiratory pressure (PEEP) increments were performed from 0 cmH 2 O to 30 cmH 2 O with 3 cmH 2 O increase every 5 minutes. Respiratory system compliance (Crs), blood gases and hemodynamics were measured at the same time. Lung regions at end-expiration and during tidal breathing were identified in EIT images.    Results  Overinflated regions contain air at end-expiration but they are not or are only minimally ventilated. Recruited regions compared to reference PEEP level contain air at end-expiration of arbitrary PEEP level but not at that of reference PEEP level. Tidally recruited/derecruited regions are not represented in lung regions at end-expiration but are ventilated during tidal breathing. The results coincided with measurements of blood gases. The coefficient for correlation between the number of recruited pixels and PaO 2 /FiO 2  was 0.89 ± 0.12 ( p  = 0.02).    Conclusion  The proposed novel EIT-based method provides information on overinflation, recruitment and cyclic alveolar collapse at the bedside, which may improve the ventilation strategies used.

Identification of regional overdistension, recruitment and cyclic alveolar collapse with electrical impedance tomography in an experimental ARDS model