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Duma and colleagues report that, in patients who achieved return of spontaneous circulation, prehospital use of epinephrine was consistently associated with a lower chance of survival, and this association showed a dose effect and persisted despite post-resuscitation interventions [1]. The accompanying editorial comment from Ewy [2] discusses the limitations and impact of this paper.

critical care

Is epinephrine during cardiac arrest associated with worse outcomes in resuscitated patients? Effect of vasopressin and catecholamines on the migration of leukocytes