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Background  Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis. Several single nucleotide polymorphisms (SNPs) in MMPs and MTs that affect genes expression have been associated with cancer risk, including breast, lung and colon.    Methods  The study group consisted of 648 unselected patients (299 with breast cancer, 199 with lung cancer, 150 with colon cancer) and 648 unaffected individuals. Five SNPs, rs1799750 in  MMP-1,  rs243865 in  MMP-2,  rs11568818 in  MMP-7,  rs2252070 in  MMP-13  and rs28366003 in  MT2A  were genotyped and serum zinc (Zn) level was measured. The cancer risk was calculated using multivariable logistic regression with respect to Zn.    Results  None of the 5 tested polymorphisms showed a correlation with cancer risk in studied groups, although for  MMP-2 ,  MMP-7  and  MT2A  non-significant differences in genotypes frequencies among cases and controls were observed.    Conclusions  Analyses of polymorphisms, rs1799750 in  MMP-1 , rs243865 in  MMP-2 , rs11568818 in  MMP-7 , rs2252070 in  MMP-13  and rs28366003 in  MT2A  in relation to serum Zn level did not show significant association with breast, lung and colon cancer risk among polish patients. Further studies are needed to verify this observation.

Polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13 and MT2A do not contribute to breast, lung and colon cancer risk in polish population