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Background  A physiologic test for estimating BPD rate has been developed by Walsh and collaborators. Actually there are not standard criteria for weaning from CPAP and/or oxygen therapy the premature babies. Aim of this study was to verify if a physiologic test, modified respect to that developed by Walsh and collaborators for estimating BPD rate, can be used as a clinical tool for weaning the premature babies from CPAP and/or oxygen therapy.    Methods  Neonates with BW 500–1250 g and GA ≤ 32 weeks, receiving FiO 2  ≤ 0.30 by hood or CPAP, were prospectively studied at 28 days of life and at 36 weeks of postmestrual age. The test was performed in 3 steps: baseline, challenge (FiO 2  and CPAP reduction to room air) and post test (room air). Monitoring of transcutaneous CO 2  was added to SpO 2  and the newborns passing the test were left in room air.    Results  Six of 23 tested babies (26%) passed the challenge at 28 days of life, 4 of 10 tested babies (40%) passed the challenge at 36 weeks. Median values of SpO 2  were significantly higher in the neonates passing the test, respect to the failing patients. At the same time median values of TcPCO 2  were significantly higher in the latter babies.    Conclusion  TcPCO 2  monitoring appeared to be a new useful parameter for failure prediction of weaning. The test represented a clinical guide because the newborns passing it were left in room air.

A modified physiologic test for bronchopulmonary dysplasia: a clinical tool for weaning from CPAP and/or oxygen-therapy the premature babies?