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Background  Coagulopathy in adult patients with traumatic brain injury (TBI) is strongly associated with unfavorable outcomes. However, few reports focus on pediatric TBI-associated coagulopathy.    Methods  We retrospectively identified children with Glasgow Coma Scale13 in a tertiary pediatric hospital from April 2012 to December 2019 to evaluate the impact of admission coagulopathy on their prognosis. A classification and regression tree (CART) analysis using coagulation parameters was performed to stratify the death risk among patients. The importance of these parameters was examined by multivariate logistic regression analysis.    Results  A total of 281 children with moderate to severe TBI were enrolled. A receiver operating characteristic curve showed that activated partial thromboplastin time (APTT) and fibrinogen were effective predictors of in-hospital mortality. According to the CART analysis, APTT of 39.2s was identified as the best discriminator, while 120mg/dL fibrinogen was the second split in the subgroup of APTT39.2s. Patients were stratified into three groups, in which mortality was as follows: 4.5% (APTT39.2s, fibrinogen>120mg/dL), 20.5% (APTT39.2s and fibrinogen120mg/dL) and 60.8% (APTT>39.2s). Furthermore, length-of-stay in the ICU and duration of mechanical ventilation were significantly prolonged in patients with deteriorated APTT or fibrinogen values. Multiple logistic regression analysis showed that APTT>39.2s and fibrinogen120mg/dL was independently associated with mortality in children with moderate to severe TBI.    Conclusions  We concluded that admission APTT>39.2s and fibrinogen120mg/dL were independently associated with mortality in children with moderate to severe TBI. Early identification and intervention of abnormal APTT and fibrinogen in pediatric TBI patients may be beneficial to their prognosis.

Relationship between admission coagulopathy and prognosis in children with traumatic brain injury: a retrospective study