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Background  WAP four-disulfide core domain protein 2 ( WFDC2 ) shows a tumor-restricted upregulated pattern of expression in ovarian cancer.    Methods  In this study, we evaluated the role of  WFCD2  in tumor mobility, invasion and metastasis of ovarian cancer in clinical tissue and in ovarian cancer cells, both in vitro and in vivo.    Results  Our results revealed  WFCD2  was overexpressed in ovarian tissues, and the expression level of  WFCD2  was associated with metastasis and lymph node metastasis. Higher expression of  WFCD2  was also observed in aggressive HO8910-PM cells than in HO8910 cells, and  WFCD2  knockdown halted cell migration, invasion, tumorigenicity and metastasis in ovarian cancer cells, both in vitro and in vivo. Knockdown of WFDC2 induced the down-regulation of ICAM-1, CD44, and MMP2.    Conclusion  In summary, our work demonstrates that  WFCD2  promotes metastasis in ovarian cancer. These findings suggest that  WFCD2  plays a critical role in promoting metastasis and may constitute a potential therapeutic target of ovarian cancer.    Electronic supplementary material  The online version of this article (doi:10.1186/s13048-017-0329-0) contains supplementary material, which is available to authorized users.

WAP four-disulfide core domain protein 2 promotes metastasis of human ovarian cancer by regulation of metastasis-associated genes