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Background  Accumulating evidence has shown that different immunotherapies for ovarian cancer might overcome barriers to resistance to standard chemotherapy. The vaccine immunotherapy may be a useful one addition to conditional chemotherapy regimens. The present study investigated the use of vaccine of ovarian cancer stem cells (CSCs) to inhibit ovarian cancer growth.    Methods  CD117 + CD44 + CSCs were isolated from human epithelial ovarian cancer (EOC) SKOV3 cell line by using a magnetic-activated cell sorting system. Pre-inactivated CD117 + CD44 + CSC vaccine was vacccinated into athymic nude mice three times, and then the mice were challenged subcutaneously with SKOV3 cells. The anti-tumor efficacy of CSC vaccine was envaluated by in vivo tumorigenicity, immune efficient analysis by flow cytometer, and enzyme-linked immunosorbent assays, respectively.    Results  The CD117 +  CD44 + CSC vaccine increased anti-ovarian cancer efficacy in that it depressed ovarian cancer growth in the athymic nude mice. Vaccination resulted in enhanced serum IFN-γ, decreased TGF-β levels, and increased cytotoxic activity of natural killer cells in the CD117 +  CD44 + CSC vaccine immunized mice. Moreover, the CSC-based vaccine significantly reduced the CD117 + CD44 + CSC as well as the aldehyde dehydrogenase 1 positive cell populations in the ovarian cancer tissues in the xenograft mice.    Conclusion  The present study provided the first evidence that human SKOV3 CD117 +  CD44 + CSC-based vaccine may induce the anti-ovarian cancer immunity against tumor growth by reducing the CD117 + CD44 + CSC population.

Effect of targeted ovarian cancer immunotherapy using ovarian cancer stem cell vaccine