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Background   FENDRR  is a long non-coding RNAs (lncRNA) that binds to polycomb repressive complexe 2 (PRC2) to epigenetically regulate the expression of its target gene. The clinical role of  FENDRR  in carcinomas remains yet to be found.    Method  Real-time polymerase chain reaction (PCR) was used to examine  FENDRR  expression in gastric cancer cell lines/tissues compared with normal epithelial cells/adjacent non-tumorous tissues. Cell proliferation assays, Wound healing assays, and in vitro and in vivo invasion and migration assays were performed to detect the biological effects of  FENDRR  in gastric cancer cells. Real-time PCR, western-blot and immunohistochemistry were used to evaluate the mRNA and protein expression of fibronectin1 (FN1). Secreted matrix metalloproteinase (MMP) activities were detected and characterized using gelatin zymography assay.    Results   FENDRR  was downregulated in gastric cancer cell lines and cancerous tissues, as compared with normal gastric epithelial cells and adjacent noncancerous tissue samples. Low  FENDRR  expression was correlated with deeper tumor invasion (p < 0.001), higher tumor stage (p = 0.001), and lymphatic metastasis (p = 0.007). Univariate and multivariate analyses indicated that low  FENDRR  expression predicted poor prognosis. Histone deacetylation was involved in the downregulation of  FENDRR  in gastric cancer cells.  FENDER  overexpression suppressed invasion and migration by gastric cancer cells in vitro, by downregulating FN1 and MMP2/MMP9 expression.    Conclusion  Low expression of the lncRNA  FENDRR  occurs in gastric cancer and is associated with poor prognosis. Thus,  FENDRR  plays an important role in the progression and metastasis of gastric cancer.

journal of hematology and oncology

Decreased expression of the long non-coding RNA FENDRR is associated with poor prognosis in gastric cancer and FENDRR regulates gastric cancer cell metastasis by affecting fibronectin1 expression