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Background Abnormal white matter is a common neurobiological change in bipolar disorder, and dysregulation of myelination in oligodendrocytes (OLs) is the cause.  Transmembrane protein 108  ( Tmem108 ), as a susceptible gene of bipolar disorder, is expressed higher in OL lineage cells than any other lineage cells in the central nervous system. Moreover,  Tmem108  mutant mice exhibit mania-like behaviors, belonging to one of the signs of bipolar disorder. However, it is unknown whether  Tmem108  regulates the myelination of the OLs. Results Tmem108  expression in the corpus callosum decreased with the development, and OL progenitor cell proliferation and OL myelination were enhanced in the mutant mice. Moreover, the mutant mice exhibited mania-like behavior after acute restraint stress and were susceptible to drug-induced epilepsy. Conclusions Tmem108  inhibited OL progenitor cell proliferation and mitigated OL maturation in the corpus callosum, which may also provide a new role of  Tmem108  involving bipolar disorder pathogenesis.

Transmembrane protein 108 inhibits the proliferation and myelination of oligodendrocyte lineage cells in the corpus callosum