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Epigenetic abnormalities play a crucial role in many tumors, including glioma. RNA methylation occurs as an epigenetic modification similar to DNA methylation and histone modification. m 6 A methylation is the most common and most intensively studied RNA methylation, which can be found throughout the RNA life cycle and exert biological functions by affecting RNA metabolism. The m 6 A modification is primarily associated with three types of protease, which are encoded by the writer, eraser and reader genes, respectively. It has been shown that the m 6 A methylation has close connections with the occurrence and development of many tumors, including glioma. In this study, the concept and the research progress of m 6 A methylation are reviewed, especially the role of m 6 A methylation in glioma. Moreover, we will discuss how glioma is paving the way to the development of new therapeutic options based on the inhibition of m 6 A deposition.

The role m6A RNA methylation is CNS development and glioma pathogenesis