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The astrocyte brain-type fatty acid binding protein ( Fabp7 ) gene expression cycles globally throughout mammalian brain, and is known to regulate sleep in multiple species, including humans. The mechanisms that control circadian  Fabp7  gene expression are not completely understood and may include core circadian clock components. Here we examined the circadian expression of  Fabp7  mRNA in the hypothalamus of core clock gene  Bmal1  knock-out (KO) mice. We observed that the circadian rhythm of  Fabp7  mRNA expression is blunted, while overall  Fabp7  mRNA levels are significantly higher in  Bmal1  KO compared to control (C57BL/6 J) mice. We did not observe any significant changes in levels of hypothalamic mRNA expression of  Fabp3  or  Fabp5 , two other fatty acid binding proteins expressed in mammalian brain, between  Bmal1  KO and control mice. These results suggest that  Fabp7  gene expression is regulated by circadian processes and may represent a molecular link controlling the circadian timing of sleep with sleep behavior.

Circadian expression of Fabp7 mRNA is disrupted in Bmal1 KO mice