English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The establishment of the functional nervous system requires coordinated development of neurons and glia in the embryo. Our understanding of underlying molecular and cellular mechanisms, however, remains limited. The developing  Drosophila  visual system is an excellent model for understanding the developmental control of the nervous system. By performing a systematic transgenic RNAi screen, we investigated the requirements of secreted proteins and cell-surface receptors for the development of photoreceptor neurons (R cells) and wrapping glia (WG) in the  Drosophila  visual system. From the screen, we identified seven genes whose knockdown disrupted the development of R cells and/or WG, including  amalgam (ama) ,  domeless (dome) ,  epidermal growth factor receptor (EGFR), kuzbanian (kuz) ,  N-Cadherin (CadN) ,  neuroglian (nrg),  and  shotgun (shg) . Cell-type-specific analysis revealed that  ama  is required in the developing eye disc for promoting cell proliferation and differentiation, which is essential for the migration of glia in the optic stalk. Our results also suggest that  nrg  functions in both eye disc and WG for coordinating R-cell and WG development.

An RNAi screen for secreted factors and cell-surface players in coordinating neuron and glia development in Drosophila