English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Deregulation of α-synuclein encoding gene ( SNCA ) is one of the important facets of Parkinson’s disease (PD) research. DNA methylation status of  SNCA -intron1 has been shown to regulate the α-synuclein expression. The present study is aimed at investigating whether methylation of  SNCA -intron1 is associated with higher expression of α-synuclein in PD. We have investigated the intron1 methylation status from 16 post-mortem brain samples comprised of 8 PD and 8 control subjects using bisulfite sequencing. We further correlated this methylation status with α-synuclein protein levels in substantia nigra of that individual using western blot analysis. We did not observe any significant difference in methylation of  SNCA -intron1 region between PD and control samples. Moreover, no correlation was observed between methylation of  SNCA -intron1 with α-synuclein level. Methylation of  SNCA -intron1 region does not correlate with α-synuclein expression in PD samples.

Hypomethylation of intron1 of α-synuclein gene does not correlate with Parkinson’s disease