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Hepatocellular carcinoma is a primary liver malignancy in which the risk of development is always multifunctional. Interleukin-6 is a proinflammatory and multifunctional cytokine, which plays an important role in the immune response, haematopoiesis and defence against viral infection. We aimed to evaluate the frequency of  Interleukin-6  mutations (rs2069837 and rs17147230) associated with genetic risk of hepatocellular carcinoma in Khyber Pakthunkhwa population. A total of 72 hepatocellular carcinoma cases and 38 controls were included in this study. The genomic DNA was extracted from the peripheral blood cells and  Interleukin-6  genotyping was performed using T-ARMS-PCR technique. Our results show a significant increase risk of developing hepatocellular carcinoma with the mutation within  Interleukin-6  gene with heterozygous G allele (rs2069837) (OR = 10.667, 95%CI = 3.923–29.001,  p  = < 0.0001) and heterozygous T allele (rs17147230) (OR = 75.385, 95%CI = 9.797–580.065,  p  = < 0.0001). However, under recessive gene model the results were insignificant in case of  Interleukin-6  rs2069837 (OR = 0.605, 95%CI = 0.217–1.689,  p  = 0.337), while significant in case of  Interleukin-6  rs17147230 (OR = 0.298, 95%CI = 0.121–0.734,  p  = 0.0085). In conclusion,  Interleukin-6  mutation is associated with hepatocellular carcinoma susceptibility. More related studies with other associated interleukins and their whole gene sequencing will be required.

Interleukin-6 polymorphisms in HCC patients chronically infected with HCV