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NRLP1  (rs12150220, rs9889625, rs9900356, rs6502867, rs2670660) and  NLRP3  (rs35829419, rs10754558) polymorphisms have been analyzed in 69 subjects with documented asbestos exposure and death for malignant pleural mesothelioma and 59 patients with documented asbestos exposure but death for other causes, all from a North East Italy. No association was found between  NLRP1  and  NLRP3  polymorphisms and susceptibility to develop mesothelioma using the general, dominant or recessive models. Also haplotype analysis did not reveal any significant association with mesothelioma. Our findings, being controversial with respect to another study on Italian patients, do suggest the need of further studies to unravel the contribution of  NLRP1  and  NLRP3  in susceptibility to mesothelioma.   Electronic supplementary material  The online version of this article (doi:10.1186/s13027-015-0022-0) contains supplementary material, which is available to authorized users.

NLRP1 and NLRP3 polymorphisms in mesothelioma patients and asbestos exposed individuals a population-based autopsy study from North East Italy