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Background  Knowledge of the impact of viable medial meniscus allograft and autograft transplantation on biochemical and mechanical properties of cartilage is needed to understand the development of joint osteoarthritis. The purpose of this study was to evaluate this relationship 6 months after viable medial meniscal autograft and allograft transplantation.    Methods  Twenty rabbits were chosen for the study. The medial menisci were excised from 14 animals and stored under tissue culture conditions for 2 weeks. Seven menisci were implanted as autografts (group A) and seven as allografts (group B). The control group consisted of six animals which underwent arthrotomy. The tibial cartilage was used for mechanical and biochemical evaluation.    Results  The respective decreases of glycosaminoglycans (GAGs) and elasticity were 13.4 and 14.8 % for group A and 30.4 and 32.6 % for group B. The differences between group A and B and between each group and the control were statistically significant. The total collagen content was significantly lower in group B.    Conclusions  The type of viable meniscal graft has an influence on the biochemical composition of the extracellular matrix (ECM) and biomechanical properties of the underlying tibial cartilage. A 1 % decrease of glycosaminoglycan content is associated with a 1.1 % decrease of cartilage elasticity. The average ratio of decrease of cartilage elasticity to that of the meniscus was 0.77 regardless of the type of meniscus graft. The viable allograft causes irreversible ECM disorder of the cartilage. Knowledge of the biochemical composition of the ECM meniscal grafts may serve as a predictor of their chondroprotective properties.

journal of orthopaedic surgery and research

The quantitative evaluation of the impact of viable medial meniscus graft type on the biochemical and biomechanical properties of the rabbit tibial cartilage