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Background  Both patient-specific dose recalculation and γ passing rate analysis are important for the quality assurance (QA) of intensity modulated radiotherapy (IMRT) plans. The aim of this study was to analyse the correlation between the γ passing rates and the volumes of air cavities ( V  air ) and bony structures ( V  bone ) in target volume of head and neck cancer.    Methods  Twenty nasopharyngeal carcinoma and twenty nasal natural killer T-cell lymphoma patients were enrolled in this study. Nine-field sliding window IMRT plans were produced and the dose distributions were calculated by anisotropic analytical algorithm (AAA), Acuros XB algorithm (AXB) and SciMoCa based on the Monte Carlo (MC) technique. The dose distributions and γ passing rates of the targets, organs at risk, air cavities and bony structures were compared among the different algorithms.    Results  The γ values obtained with AAA and AXB were 95.6 ± 1.9% and 96.2 ± 1.7%, respectively, with 3%/2 mm criteria ( p  > 0.05). There were significant differences ( p  < 0.05) in the γ values between AAA and AXB in the air cavities (86.6 ± 9.4% vs. 98.0 ± 1.7%) and bony structures (82.7 ± 13.5% vs. 99.0 ± 1.7%). Using AAA, the γ values were proportional to the natural logarithm of  V  air  (R 2  = 0.674) and inversely proportional to the natural logarithm of  V  bone  (R 2  = 0.816). When the  V  air  in the targets was smaller than approximately 80 cc or the  V  bone  in the targets was larger than approximately 6 cc, the γ values of AAA were below 95%. Using AXB, no significant relationship was found between the γ values and  V  air  or  V  bone .    Conclusion  In clinical head and neck IMRT QA, greater attention should be paid to the effect of  V  air  and  V  bone  in the targets on the γ passing rates when using different dose calculation algorithms.

Correlation between the γ passing rates of IMRT plans and the volumes of air cavities and bony structures in head and neck cancer