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Background  To explore the differences and correlations between the target volumes defined using preoperative prone diagnostic magnetic resonance imaging (MRI) and postoperative prone computed tomography (CT) simulation imaging based on deformable image registration (DIR) for external-beam partial breast irradiation (EB-PBI) after breast-conserving surgery (BCS).    Methods  Eighteen breast cancer patients suitable for EB-PBI were enrolled. Preoperative prone diagnostic MRI and postoperative prone CT scan sets for all the patients were acquired during free breathing. Target volumes and ipsilateral breast were all contoured by the same radiation oncologist. The gross tumor volume (GTV) delineated on the preoperative MRI images was denoted as the GTV preMR  and the tumor bed (TB) delineated on the postoperative prone CT images was denoted as the GTV postCT . The MIM software system was used to deformably register the MRI and CT images.    Results  When based on the coincidence of the compared target centers, there were statistically significant increases in the conformity index (CI) and degree of inclusion (DI) values for GTV postCT -GTV preMR , GTV postCT -CTV preMR + 10 , CTV postCT + 10 -GTV preMR,  and CTV postCT + 10 -CTV preMR + 10  when compared with those based on the DIR of the thorax ( Z  = − 3.724, − 3.724, − 2.591, − 3.593, all  P <  0.05;  Z  = -3.724, − 3.724, − 3.201, − 3.724, all  P <  0.05, respectively).    Conclusions  Although based on DIR, there was relatively poor spatial overlap between the preoperative prone diagnostic MRI images and the postoperative prone CT simulation images for either the whole breast or the target volumes. Therefore, it is unreasonable to use preoperative prone diagnostic MRI images to guide postoperative target delineation for EB-PBI.

radiation oncology

A comparative study based on deformable image registration of the target volumes for external-beam partial breast irradiation defined using preoperative prone magnetic resonance imaging and postoperative prone computed tomography imaging