English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  The deformable image registration (DIR) technique has the potential to realize the dose accumulation during radiotherapy. This study will analyze the feasibility of evaluating dose-volume parameters for the heart and left ventricular myocardium (LVM) by applying DIR.    Methods  The electrocardiograph-gated four-dimensional CT (ECG-gated 4DCT) data of 21 patients were analyzed retrospectively. The heart and LVM were contoured on 20 phases of 4DCT (0%, 5%,…,95%). The heart and LVM in the minimum volume/dice similarity coefficient (DSC) phase (Volume  min /DSC  min ) were deformed to the maximum volume/DSC phase (Volume  max / DSC  max ), which used the intensity-based free-form DIR algorithm of MIM software. The dose was deformed according to the deformation vector. The variations in volume, mean dose (D mean ), V 20 , V 30  and V 40  for the heart and LVM before and after DIR were compared, and the reference phase was the Volume  max /DSC  max  phase.    Results  For the heart, the difference between the pre- and post-registration Volume  min  and Volume  max  were reduced from 13.87 to 1.72%; the DSC was increased from 0.899 to 0.950 between the pre- and post-registration DSC  min  phase relative to the DSC  max  phase. The post-registration D mean , V 20 , V 30  and V 40  of the heart were statistically significant compared to those in the Volume  max /DSC  max  phase ( p  < 0.05). For the LVM, the difference between the pre- and post-registration Volume  min  and Volume  max  were only reduced from 18.77 to 17.38%; the DSC reached only 0.733 in the post-registration DSC  min  phase relative to the DSC  max  phase. The pre- and post-registration volume, D mean , V 20 , V 30  and V 40  of the LVM were all statistically significant compared to those in the Volume  max /DSC  max  phase ( p  < 0.05).    Conclusions  There was no significant relationship between the variation in dose-volume parameters and the variation in the volume and morphology for the heart; however, the inconsistency of the variation in the volume and morphology for the LVM was a major factor that led to uncertainty in the dose-volume evaluation. In addition, the individualized local deformation registration technology should be applied in dose accumulation for the heart and LVM.

radiation oncology

Impact of deformable image registration on dose accumulation applied electrocardiograph-gated 4DCT in the heart and left ventricular myocardium during esophageal cancer radiotherapy