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Background  We evaluated dynamic changes in  18 F–borono-L-phenylalanine ( 18 F–BPA) uptake in unresectable, advanced, or recurrent squamous cell carcinoma of the head and neck (SCC) and malignant melanoma (MM) during boron neutron capture therapy (BNCT) patient selection.    Methods  Dynamic changes in the maximum standardized uptake value (SUVmax), tumor-to-normal tissue ratio (TNR), and tumor-to-blood pool ratio (TBR) for  18 F–BPA were evaluated in 20 patients with SCC and 8 patients with MM.    Results  SUVmax in SCC tumors decreased significantly from 30 to 120 min. There was a non-statistically significant decrease in SUVmax for SCC tumors from 30 to 60 min and from 60 to 120 min. Patients with MM had nonsignificant SUVmax changes in  18 F–BPA uptake on delayed imaging. Nonsignificant  18 F–BPA TNR and TBR changes were seen in patients with SCC and MM.    Conclusions  Dynamic changes in SUVmax for  18 F–BPA uptake had a washout pattern in SCC and a persistent pattern in MM. Dynamic  18 F–BPA -PET studies should be performed to investigate the pharmacokinetics of  18 F–BPA in humans and select appropriate candidates who may benefit from BNCT.

radiation oncology

Dynamic changes in 18F-borono-L-phenylalanine uptake in unresectable, advanced, or recurrent squamous cell carcinoma of the head and neck and malignant melanoma during boron neutron capture therapy patient selection