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Background  Chronic Periodontitis (CP) is a common inflammatory disease affects supporting tissues of the  teeth  and can lead to tooth loss. The objective of this study was to determine the relationship between polymorphisms in the  IL-28B  gene and chronic periodontitis in an Iranian population.    Methods  Two hundred and ten CP patients and one hundred healthy subjects were enrolled in the present case-control study. The  rs12979860  and  rs8099917  SNPs were identified using RFLP and T-ARMS-PCR methods respectively.    Results  SNP analysis revealed that the G allele of  rs8099917  SNP and T allele of  rs12979860  SNP increased susceptibility to CP compared to the A allele and C allele ( p  < 0.0001, OR = 2.712, CI = 1.783-4.126;  p  < 0.0001, OR = 2.538, CI = 1.784-3.613 respectively). In addition, the CT/GT, TT/GG and TT/GT haplotypes were predominant in CP patients and significantly associated with the increased risk of CP.    Conclusion    IL-28B  polymorphisms may be useful predictive factors for chronic periodontitis and correlated to the susceptibility to CP infection in our population.

The association between interleukin-28B gene polymorphisms as a potential biomarker and the risk of chronic Periodontitis in an Iranian population