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Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor.  We report a case of a dome-type carcinoma of the cecum in a 57 year old female.  The sessile, non-polypoid lesion histologically consisted of a tubulovillous adenoma with low-grade dysplasia.  The submucosal invasive component showed low-grade architectural features that included cystically dilated glands containing eosinohilic debris. Immunohistochemical studies displayed retention of the four mistmach repair proteins, consistent with a stable phenotype. After 3 years, the patient remains free of recurrence.  A literature review highlighted striking similarities between dome-type carcinoma and the gut-associated lymphoid tissue carcinoma, the two sharing an intimate association with the gut associated lymphoid tissue.  The two variants might therefore be grouped into a unified category.

DOME/GALT type adenocarcimoma of the colon: a case report, literature review and a unified phenotypic categorization