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Background  Reactive airway dysfunction syndrome (RADS), also called irritant-induced asthma, is a type of occupational asthma that can occur within a very short period of latency. The study sought to investigate the influence of sulfur dioxide (SO 2 ) exposure on CD19+ cells and nasal epithelial injury.    Methods  We investigated the effects of SO 2  on CD19 expression and morphological changes of nasal epithelia in rats. In the study, 20 rats were randomly divided into the SO 2  exposure group that were exposed to 600 ppm SO 2 , 2 h/day for consecutive 7 days, and the control group that were exposed to filtered air).    Results  Inhalation of high concentration of SO 2 significantly reduced CD19 expression at both the mRNA transcript and protein levels, and reduced the percentages of CD19 +  cells and CD19 + /CD23 +  cells in the nasal septum. However, inhalation of high concentration of SO 2  did not affect immunoglobulin (Ig) G, IgA and IgE levels in the serum and nasal septum. More importantly, SO 2  exposure also caused mild structural changes of the nasal septum.    Conclusion  Our results reveal that inhalation of a high concentration of SO 2  reduces CD19 expression and causes structural change of the nasal septum in rats.

Sulfur dioxide exposure reduces the quantity of CD19+ cells and causes nasal epithelial injury in rats