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Background  The present study was designed to study anxiolytic property of methanolic extracts of  Urtica urens;  an important and commonly used for its medicinal properties belongs to urticaceae family.    Methods  The anxiolytic activity was evaluated with the adult mice by hole board test, and the light–dark box test, and motor coordination with the rota rod test. The efficacy of the plant extract (100–400 mg/kg) was compared with the standard anxiolytic drug diazepam (1 mg/kg i.p.)    Results  The extract increased the time spent in the brightly-lit chamber of the light/dark box, as well as in the number of times the animal crossed from one compartment to the other. Performance on the rota rod was unaffected. In the hole board test, the extract significantly increased both head-dip counts and head-dip duration.  Urtica urens , in contrast to diazepam, had no effect on locomotion.    Conclusions  These results provides support for anxiolytic activity of  Urtica urens , in line with its medicinal traditional use, and may also suggest a better side-effect profile of  Urtica urens  relative to diazepam.

Evaluation of anxiolytic activity of methanolic extract of Urtica urens in a mice model