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Exercise is currently seen as an effective treatment for major depressive disorder (MDD). However, existing studies have focused mainly on mild-to-moderate depression. The moderate positive effect of exercise found in meta-analyses concerning these studies differs, however, from the harsh daily clinical practice, when trying to implement exercise as an adjunctive treatment. We aimed to evaluate the feasibility of aerobic exercise in MDD and identify future problems for implementation.

EFFORT-D study process evaluation: challenges in conducting a trial into the effects of running therapy in patients with major depressive disorder