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Background  Though Internet gaming disorder (IGD) is considered to share similar genetic vulnerability with substance addictions, little has been explored about the role of the genetic variants on IGD. This pilot study was designed to investigate the association of the  Taq1A  polymorphism of the ankyrin repeat and kinase domain containing 1 ( ANKK1 ) gene and  C957T  and −  141C  of the dopamine D2 receptor ( DRD2 ) with IGD and their role on the personality and temperament traits in IGD among adult population.    Methods  Sixty-three subjects with IGD and 87 control subjects who regularly played Internet games were recruited. Self-administered questionnaires on self-control, dysfunctional impulsivity, and temperament and character domains were done. The  Taq1A ANKK1  and the  C957T  and −  141C ins/del  from the  DRD2  genes were genotyped using the specific TaqMan PCR assay.    Results  The distributions of allele and genotype frequencies were not significantly different between the IGD and control groups in both genders. In male, excessive gaming and use of gaming to escape from a negative feeling were associated with the  del−  genotype of the −  141C . Among IGD, the  del + genotype was associated with higher novelty seeking. Logistic regression showed no predictive value of these polymorphisms for IGD when using age and gender as covariates.    Conclusions  Though no direct association of the  Taq1A ANKK1  and  C957T DRD2  variants with IGD were observed, the −  141C  polymorphism may play a role in IGD via mediating symptoms or temperament traits.    Electronic supplementary material  The online version of this article (10.1186/s12991-017-0168-9) contains supplementary material, which is available to authorized users.

An association study of Taq1A ANKK1 and C957T and − 141C DRD2 polymorphisms in adults with internet gaming disorder: a pilot study